Description

(4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is a high-value, protected boronic ester derivative featuring a benzylic alcohol functional group. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant boronic ester reagent for forming carbon-carbon bonds with aryl/vinyl halides, enabling the construction of biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific substituted biphenyl structures.
• Liquid Crystal & OLED Materials: Acts as a building block for creating complex organic molecules used in electronic displays and organic light-emitting diodes.
• Polymer Chemistry: Incorporated into specialty monomers to produce polymers with tailored thermal, optical, or mechanical properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, process chemistry, and methodology development in academic and industrial labs.

Basic Information

Product Name	(4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol
CAS No.	1400755-04-5
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	3-(Hydroxymethyl)-4-methylphenylboronic acid pinacol ester; (3-(Hydroxymethyl)-4-methylphenyl)boronic acid pinacol ester; (4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol; 2-(3-(Hydroxymethyl)-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-(hydroxymethyl)-4-methylphenyl)boronate; CAS 1400755-04-5; Boronic ester intermediate 1400755-04-5
EINECS	Contact for details

Quality Control

Every batch of (4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and GC to confirm identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.