Description

2-(3-Bromo-2-Fluoro-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, specifically the Suzuki-Miyaura reaction, which is fundamental for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis. CAS No. 1400220-51-0.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex fluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated biphenyl motifs.
• Material Science: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for constructing diverse compound libraries via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts.
• Fluorine Chemistry: Exploits the ortho-fluoro substituent for studying steric and electronic effects in molecular design and for further functionalization.

Basic Information

Item	Details
Product Name	2-(3-Bromo-2-Fluoro-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1400220-51-0
Molecular Formula	C12H15BBrFO2
Molecular Weight	301.96 g/mol
Synonyms	3-Bromo-2-fluorophenylboronic acid pinacol ester; (3-Bromo-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-3-bromophenylboronic acid pinacol ester; Pinacol (3-bromo-2-fluorophenyl)boronate; 2-(3-Bromo-2-fluorophenyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; 1400220-51-0; B-(3-Bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Bromo-2-Fluoro-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency that meets the stringent requirements of research and production applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.