Description

4,4,5,5-Tetramethyl-2-(2-(p-Tolyl)Prop-1-En-1-Yl)-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester, essential for modern synthetic chemistry. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds with high efficiency and selectivity. This compound is critical for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used to construct complex molecular scaffolds for novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology & Medicinal Chemistry: Enables the late-stage functionalization and diversification of complex molecules in drug discovery programs.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2-(p-Tolyl)Prop-1-En-1-Yl)-1,3,2-Dioxaborolane
CAS No.	1398771-21-5
Molecular Formula	C₁₈H₂₇BO₂
Molecular Weight	286.22 g/mol
Synonyms	2-(2-(4-Methylphenyl)prop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-2-(2-(p-Tolyl)prop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; p-Tolylpropenyl Pinacol Boronate; 4-Methylstyryl Pinacolboronate; Boronic acid, B-[2-(4-methylphenyl)-1-propen-1-yl]-, pinacol ester; (E)-4-Methyl-β-styrylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(2-(p-Tolyl)Prop-1-En-1-Yl)-1,3,2-Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (typically by NMR and HPLC), identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Recommended storage temperature is 2-8°C for extended periods.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.