Description

1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclobutanol is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutanol moiety and a protected boronic acid pinacol ester. This compound is a critical building block in modern synthetic organic chemistry, enabling the precise construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring cyclobutane rings.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester group serves as a stable, reactive handle for forming carbon-carbon bonds with aryl/vinyl halides, essential for constructing biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with complex cyclic structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular geometry is crucial.
• Chemical Biology & Probe Development: Useful for creating molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific boronic ester derivative.

Basic Information

Item	Details
Product Name	1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclobutanol
CAS No.	1398331-98-0
Molecular Formula	C16H23BO3
Molecular Weight	274.16 g/mol
Synonyms	4-(Cyclobutanol-1-yl)phenylboronic acid pinacol ester; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutanol; (4-(1-Hydroxycyclobutyl)phenyl)boronic acid pinacol ester; 4-(1-Hydroxycyclobutyl)benzeneboronic acid pinacol ester; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol; Cyclobutyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol; B-[4-(1-Hydroxycyclobutyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1-[4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclobutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.