Description

1H-Benzotriazole, 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, functionalized benzotriazole derivative containing a pinacol boronate ester group, making it a versatile building block for advanced organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in pharmaceutical and materials chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers and small molecules used in OLEDs, OFETs, and other organic semiconductor applications.
• Ligand & Catalyst Development: Employed in the creation of novel nitrogen-containing ligands for transition metal catalysis.
• Chemical Biology & Probe Synthesis: Useful for incorporating benzotriazole scaffolds into molecular probes and bio-conjugation reagents.
• Academic & Contract Research: Essential reagent for methodological development and complex molecule synthesis in academic and CRO laboratory settings.

Basic Information

Product Name	1H-Benzotriazole, 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1396753-41-5
Molecular Formula	C15H22BN3O2
Molecular Weight	287.17 g/mol
Synonyms	1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzotriazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-benzotriazole; 1-Methyl-1H-benzotriazol-5-ylboronic acid pinacol ester; 1-Methyl-5-(pinacolatoboryl)-1H-benzotriazole; 1-Methyl-1H-benzo[d][1,2,3]triazol-5-ylboronic acid pinacol ester; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzotriazole
EINECS	Contact for details

Quality Control

Every batch of our 1H-Benzotriazole, 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC/NMR), identity confirmation, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronate ester functionality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.