Description

4,4,5,5-Tetramethyl-2-(Oxetan-3-Yl)-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a cyclic boronic ester featuring an oxetane moiety. This compound is critical for modern synthetic chemistry, enabling efficient and selective cross-coupling reactions to construct complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry, ligand synthesis, and polymer science.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex organic molecules, particularly in pharmaceutical intermediates.
• Medicinal Chemistry & Drug Discovery: Used as a versatile building block for introducing the oxetane pharmacophore, which can improve metabolic stability, solubility, and other key drug-like properties of candidate molecules.
• Agrochemical Synthesis: Employed in the research and development of novel active ingredients for crop protection products.
• Materials Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and functional materials.
• Ligand and Catalyst Development: Utilized in the preparation of novel boron-containing ligands for catalysis and chemical sensing applications.
• Chemical Biology Probes: Acts as a handle for bioconjugation and the synthesis of probes for studying biological systems.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(Oxetan-3-Yl)-1,3,2-Dioxaborolane
CAS No.	1396215-84-1
Molecular Formula	C11H21BO3
Molecular Weight	212.10 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)oxetane; Oxetan-3-ylboronic acid pinacol ester; 2-(Oxetan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Oxetanylboronic acid pinacol ester; 3-Boroxetane pinacol ester; (Oxetan-3-yl)BPin; 1396215-84-1; Oxetane-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(Oxetan-3-Yl)-1,3,2-Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including NMR, HPLC, and GC analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical: 97-99%)
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.