Description

Lithium (5-Methoxypyridin-2-Yl)Trihydroxyborate is a high-purity, organoboron reagent primarily used as a key synthetic intermediate in advanced pharmaceutical and agrochemical research. This compound is valued for its role in cross-coupling reactions, particularly Suzuki-Miyaura couplings, enabling the efficient construction of complex biaryl structures. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking reliable, high-quality building blocks for novel compound libraries and active ingredient synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Suzuki-Miyaura Cross-Coupling Reactions: Functions as a stable boronate ester reagent for palladium-catalyzed cross-couplings with various organic halides.
• Chemical Biology & Medicinal Chemistry: Employed in fragment-based drug discovery and the synthesis of chemical probes for biological target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-fidelity boron reagents.

Basic Information

Item	Details
Product Name	Lithium (5-Methoxypyridin-2-Yl)Trihydroxyborate
CAS No.	1393822-92-8
Molecular Formula	C6H7BLiNO4
Molecular Weight	174.88 g/mol
Synonyms	Lithium (5-Methoxypyridin-2-yl)boronate; 2-(5-Methoxy-2-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane lithium salt (common precursor); 5-Methoxy-2-pyridineboronic acid lithium salt; (5-Methoxypyridin-2-yl)boronic acid lithium salt; Lithium 5-methoxypyridine-2-boronate; 2-(5-Methoxypyridinyl)boronic acid lithium complex; Boronic acid, B-(5-methoxy-2-pyridinyl)-, lithium salt (1:1)
EINECS	Contact for details

Quality Control

Our Lithium (5-Methoxypyridin-2-Yl)Trihydroxyborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.