Description

1-(3-Iodo-5-Trifluoromethyl-Phenyl)-Ethanone is a high-purity, multi-functional aromatic ketone building block characterized by its unique trifluoromethyl and iodo substituents. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals where its halogenated structure enables precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Material Science Research: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	1-(3-Iodo-5-Trifluoromethyl-Phenyl)-Ethanone
CAS No.	1393557-53-3
Molecular Formula	C9H6F3IO
Molecular Weight	314.05 g/mol
Synonyms	3'-Iodo-5'-(trifluoromethyl)acetophenone; 1-[3-Iodo-5-(trifluoromethyl)phenyl]ethanone; 3-Iodo-5-trifluoromethylacetophenone; Ethanone, 1-[3-iodo-5-(trifluoromethyl)phenyl]-; 1-(3-Iodo-5-trifluoromethylphenyl)ethan-1-one; 3-Iodo-α,α,α-trifluoro-m-acetophenone
EINECS	Contact for details

Quality Control

Our 1-(3-Iodo-5-Trifluoromethyl-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.