Description

2-(Difluoromethyl)Pyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant interest in modern synthetic chemistry. Its value lies in the strategic incorporation of the difluoromethyl group, a key motif for modulating the physicochemical and metabolic properties of bioactive molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting enzyme inhibition and receptor modulation.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery for central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Medicinal Chemistry Research: Used to introduce the difluoromethyl group into lead compounds to improve metabolic stability, lipophilicity, and membrane permeability during structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Serves as a key precursor or scaffold in the design and synthesis of novel protease inhibitors, leveraging the pyrrolidine core.
• Agrochemical Synthesis: Employed in the research and development of new generation herbicides, fungicides, and pesticides where the difluoromethyl moiety can enhance biological activity.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes and tool compounds for investigating biological pathways and target engagement.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production of candidate drugs under Good Manufacturing Practice (GMP) guidelines where required.

Basic Information

Product Name	2-(Difluoromethyl)Pyrrolidine Hydrochloride
CAS No.	1393541-22-4
Molecular Formula	C5H10F2N•HCl
Molecular Weight	157.60 (Free base) / 194.06 (HCl salt)
Synonyms	2-(Difluoromethyl)pyrrolidine HCl; Pyrrolidine, 2-(difluoromethyl)-, hydrochloride; 2-(Difluoromethyl)-1-azacyclopentane hydrochloride; 2-(Difluoromethyl)pyrrolidinium chloride; (2R)-2-(Difluoromethyl)pyrrolidine hydrochloride (for chiral form); (2S)-2-(Difluoromethyl)pyrrolidine hydrochloride (for chiral form); 2-Difluoromethylpyrrolidine hydrochloride; 1393541-22-4
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, assay, and impurity profile. We adhere to relevant quality management standards, and specifications can be aligned with client requirements for advanced applications, including those under cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.