Description

[3,5-Difluoro-4-(Oxan-4-Yloxy)Phenyl]Methanamine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorophenyl ether scaffold linked to a primary amine. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring structurally complex and fluorinated molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its difluoro and tetrahydropyranyloxy substituents, which can modulate potency, metabolic stability, and bioavailability.
• API Synthesis: Incorporated into the final synthetic route of complex target molecules, leveraging the reactive primary amine for further derivatization (e.g., amide coupling, reductive amination).
• Bioconjugation & Probe Development: The amine functionality allows for conjugation to fluorescent tags, biotin, or other reporter molecules for use in biochemical assays and diagnostic probe development.
• Agrochemical Research: Potential application as an intermediate in the synthesis of new generation herbicides or fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Can serve as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced materials with specific surface properties.

Basic Information

Product Name	[3,5-Difluoro-4-(Oxan-4-Yloxy)Phenyl]Methanamine
CAS No.	1393330-71-6
Molecular Formula	C12H15F2NO2
Molecular Weight	243.25 g/mol
Synonyms	(3,5-Difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)methanamine; 4-(Aminomethyl)-2,6-difluoro-1-(tetrahydro-2H-pyran-4-yloxy)benzene; 1-(3,5-Difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)methanamine; 4-(Aminomethyl)-2,6-difluorophenyl tetrahydro-2H-pyran-4-yl ether; THP-Protected Difluoro Benzylamine Intermediate; 1393330-71-6; [3,5-Difluoro-4-(tetrahydropyran-4-yloxy)phenyl]methanamine
EINECS	Contact for details

Quality Control

Our [3,5-Difluoro-4-(Oxan-4-Yloxy)Phenyl]Methanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time matches reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0% (Area Percent)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.