Description

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D]Thiazol-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected carbamate group and a pinacol boronate ester, making it a versatile building block for modern synthetic chemistry. This compound is specifically designed for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly those targeting kinase inhibition and other therapeutic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides requiring specific heterocyclic architectures.
• Material Science: Serves as a building block for creating organic electronic materials and functional polymers via cross-coupling.
• Chemical Biology: Employed in the synthesis of probes and labeled compounds for target identification and binding studies.
• Process Chemistry: Utilized in route scouting and scale-up for the efficient production of benzothiazole-containing molecules.
• Academic & Contract Research: A valuable reagent for methodology development and library synthesis in medicinal chemistry programs.

Basic Information

Product Name	tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D]Thiazol-2-Ylcarbamate
CAS No.	1392846-50-2
Molecular Formula	C18H25BN2O4S
Molecular Weight	376.28 g/mol
Synonyms	2-(((tert-Butoxy)carbonyl)amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazol-2-yl tert-butyl carbamate; tert-Butyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazol-2-yl]carbamate; BOC-Protected 5-Boronic Acid Pinacol Ester Benzothiazole; 5-(Bpin)-Benzothiazole-2-Boc-carbamate
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D]Thiazol-2-Ylcarbamate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.