Description

2-[(3,5-Difluorophenyl)Methyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1392150-21-8 is a high-purity, organoboron reagent belonging to the pinacol boronic ester class, serving as a critical synthetic intermediate. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for researchers and manufacturers in pharmaceutical development and agrochemical synthesis who require reliable, high-quality building blocks for drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing difluorophenyl motifs, particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the introduction of the difluorophenyl group enhances biological activity and stability.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for palladium-catalyzed carbon-carbon bond formation, enabling the efficient and selective synthesis of complex, functionalized biaryl structures.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate ligands and organometallic catalysts used in asymmetric synthesis.
• Life Sciences & Diagnostics: Potential use in the development of molecular probes, biomarkers, and diagnostic agents due to its boronic ester functionality.

Basic Information

Item	Details
Product Name	2-[(3,5-Difluorophenyl)Methyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1392150-21-8
Molecular Formula	C13H17BF2O2
Molecular Weight	254.08 g/mol
Synonyms	(3,5-Difluorobenzyl)boronic acid pinacol ester; 1-(3,5-Difluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3,5-Difluorophenyl)methylboronic acid pinacol ester; Pinacol (3,5-Difluorobenzyl)boronate; 2-[(3,5-Difluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3,5-Difluorobenzyl)BPin; 3,5-Difluorobenzylboronic Acid Pinacol Ester; B-(3,5-Difluorobenzyl)boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our production of 2-[(3,5-Difluorophenyl)Methyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.