Description

4,4,5,5-Tetramethyl-2-(Tetrahydro-2H-Pyran-3-Yl)-1,3,2-Dioxaborolane is a specialized organoboron reagent, specifically a substituted dioxaborolane, that serves as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile boronic ester for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex carbon-carbon bonds. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for complex synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex molecular architectures in active pharmaceutical ingredient (API) development via palladium-catalyzed cross-coupling.
• Agrochemical Research: Used in the synthesis of novel compounds for crop protection and herbicide development.
• Material Science: Serves as a precursor for creating organic electronic materials, including polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of bioconjugates, probes, and libraries for drug discovery and target identification.
• Catalyst & Ligand Development: Acts as a building block for synthesizing novel bidentate ligands and organometallic catalysts.
• Academic & Industrial R&D: A fundamental tool for methodology development and exploratory synthesis in organic chemistry laboratories.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(Tetrahydro-2H-Pyran-3-Yl)-1,3,2-Dioxaborolane
CAS No.	1391850-39-7
Molecular Formula	C11H21BO3
Molecular Weight	212.10 g/mol
Synonyms	2-(Oxan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)tetrahydro-2H-pyran; Tetrahydro-2H-pyran-3-ylboronic acid pinacol ester; THP-Protected Pinacol Boronate; 3-Pinacolatoboryltetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(Tetrahydro-2H-Pyran-3-Yl)-1,3,2-Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.