Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its protected boronic ester functionality, which is essential for modern cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecules. This compound is critically needed by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to create complex biaryl and heterobiaryl structures prevalent in modern medicinal chemistry.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides with improved efficacy and selectivity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1H-Pyrazole
CAS No.	1391835-53-2
Molecular Formula	C₁₆H₂₁BN₂O₄S
Molecular Weight	348.23 g/mol
Synonyms	1H-Pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-tolylsulfonyl)-1H-pyrazole; 1-Tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-Pinacolatoboryl-1-tosyl-1H-pyrazole; 4-BPin-1-Ts-Pyrazole; Pyrazole Boronic Acid Pinacol Ester Tosyl Protected; Borylation Reagent Intermediate
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.