Description

(Cyclopropylethynyl) 2-Fluorobenzene is a specialized fluorinated aromatic building block featuring a cyclopropylethynyl substituent. This unique molecular architecture makes it a valuable intermediate for constructing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry, including the synthesis of novel active ingredients and functional materials. The compound's structure offers strategic vectors for further functionalization, enabling the exploration of new chemical space.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in constructing fluorinated bioactive molecules.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorobenzene moiety can enhance biological activity and stability.
• Material Science Precursor: Serves as a building block for advanced organic materials, such as liquid crystals or organic semiconductors, where its rigid, conjugated structure is beneficial.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to create more complex molecular architectures.
• Medicinal Chemistry Probe: Utilized in structure-activity relationship (SAR) studies to investigate the impact of the cyclopropylethynyl group on pharmacokinetic properties.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research focused on developing new methodologies for incorporating fluorine into organic molecules.

Basic Information

Item	Details
Product Name	(Cyclopropylethynyl) 2-Fluorobenzene
CAS No.	1391053-47-6
Molecular Formula	C11H9F
Molecular Weight	160.19 g/mol
Synonyms	1-Cyclopropyl-2-(2-fluorophenyl)ethyne; 2-Fluoro-1-(2-cyclopropylethynyl)benzene; 1-Ethynyl-2-fluorobenzene, cyclopropyl derivative; (2-Fluorophenyl)(cyclopropyl)acetylene; o-Fluoro(cyclopropylethynyl)benzene; 2-Fluorobenzene, (cyclopropylethynyl)-; Cyclopropylethynyl-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our (Cyclopropylethynyl) 2-Fluorobenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer requirements. We are committed to supplying material that meets the stringent standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.