Description

4,4-Difluoro-1-Methylcyclohexane-1-Carboxylic Acid is a high-purity fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. This compound matters for its unique structural features, combining a sterically hindered, fluorinated cyclohexane ring with a reactive carboxylic acid group, enabling precise modifications to molecular properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals designed for unique surface properties, chemical resistance, or low dielectric constants.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and the effects of geminal difluorination on conformational and electronic properties in cyclic systems.

Basic Information

Product Name	4,4-Difluoro-1-Methylcyclohexane-1-Carboxylic Acid
CAS No.	1389313-41-0
Molecular Formula	C9H14F2O2
Molecular Weight	192.20 g/mol
Synonyms	1-Methyl-4,4-difluorocyclohexanecarboxylic Acid; 4,4-Difluoro-1-methyl-1-cyclohexanecarboxylic Acid; 1-Cyclohexanecarboxylic acid, 4,4-difluoro-1-methyl-; Difluoromethylcyclohexanecarboxylic Acid; 4,4-Difluoro-α-methylcyclohexanecarboxylic Acid; 1389313-41-0; 4,4-Difluoro-1-methylcyclohexane carboxylic acid
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-Methylcyclohexane-1-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates, from early-stage R&D to scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is compatible with strong acids and organic solvents but should be kept away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.