Description

1-[[3-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Carbonyl]Pyrrolidine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which are fundamental to modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting oncology and central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial organoboron reagent for constructing biaryl and heterobiaryl scaffolds, which are common motifs in many modern pharmaceuticals.
• Medicinal Chemistry Research: Enables rapid analog synthesis and structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Can be incorporated into molecules used to study biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with complex aromatic structures.

Basic Information

Product Name	1-[[3-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Carbonyl]Pyrrolidine
CAS No.	1386860-56-5
Molecular Formula	C18H26BNO3
Molecular Weight	315.22 g/mol
Synonyms	(3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)pyrrolidine; 1-[3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]pyrrolidine; (3-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(pyrrolidin-1-yl)methanone; Pyrrolidine, 1-[[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbonyl]-; 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-pyrrolidinylbenzamide; Boronic ester pyrrolidine intermediate CAS 1386860-56-5
EINECS	Contact for details

Quality Control

Our production of 1-[[3-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Carbonyl]Pyrrolidine adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized and released against comprehensive specifications using advanced analytical techniques including HPLC, NMR, and LC-MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.