Description

1,3,2-Dioxaborolane, 2-(2-Chloro-3-Methylphenyl)-4,4,5,5-Tetramethyl- is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters as a versatile reagent for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing substituted biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific chlorinated and methylated aromatic systems.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed to create novel boron-containing ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities producing bespoke compounds for clients.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-(2-Chloro-3-Methylphenyl)-4,4,5,5-Tetramethyl-
CAS No.	1386860-54-3
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	2-(2-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Chloro-3-methylphenyl)boronic acid pinacol ester; 2-Chloro-3-methylbenzeneboronic acid pinacol ester; 2-Chloro-3-methylphenylboronic acid pinacol ester; 2-(2-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; (2-Chloro-m-tolyl)boronic acid pinacol ester; PINACOL (2-CHLORO-3-METHYLPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-(2-Chloro-3-Methylphenyl)-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.