Description

4-[2-(Trifluoromethyl)Phenyl]Oxan-4-Amine is a high-value, fluorinated organic building block characterized by its unique tetrahydropyranyl amine structure. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the trifluoromethyl group for improved bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers or polymers with tailored properties for advanced materials.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services offered by CDMOs (Contract Development and Manufacturing Organizations).

Basic Information

Product Name	4-[2-(Trifluoromethyl)Phenyl]Oxan-4-Amine
CAS No.	1385696-28-5
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	4-Amino-4-[2-(trifluoromethyl)phenyl]tetrahydro-2H-pyran; 4-[2-(Trifluoromethyl)phenyl]-4-aminotetrahydropyran; 4-(2-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-amine; 2H-Pyran-4-amine, tetrahydro-4-[2-(trifluoromethyl)phenyl]-; 4-(α,α,α-Trifluoro-o-tolyl)-4-aminotetrahydropyran
EINECS	Contact for details

Quality Control

Our 4-[2-(Trifluoromethyl)Phenyl]Oxan-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.