Description

3-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the strategic combination of an electron-donating amino group, a versatile nitrile function, and a protected boronic acid moiety, enabling precise and efficient cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to construct complex molecular architectures for active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, leveraging its ability to form biaryl linkages.
• Material Science: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as OLEDs and OFETs.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of molecular probes and sensors.
• Ligand & Catalyst Development: Utilized in the synthesis of novel bidentate or tridentate ligands for transition metal catalysis.
• Polymer Chemistry: Incorporated into polymer backbones to introduce boronate functionality for stimuli-responsive or self-healing materials.

Basic Information

Product Name	3-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
CAS No.	1384855-68-8
Molecular Formula	C₁₃H₁₇BN₂O₂
Molecular Weight	244.10 g/mol
Synonyms	2-(4-Cyano-2-aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Amino-4-(pinacolatoboron)benzonitrile; 4-Cyano-2-aminophenylboronic acid pinacol ester; 2-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; Pinacol 3-Amino-4-cyanophenylboronate; (3-Amino-4-cyanophenyl)boronic acid pinacol ester; B-(3-Amino-4-cyanophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.