Description

2-Amino-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multifunctional boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to modern organic synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the boronic ester functionality for structural diversification.
• Material Science Research: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, where its conjugated structure is advantageous.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive handles.
• Academic & R&D Laboratories: A versatile reagent for methodological development in organic chemistry and catalysis studies.
• Liquid Crystal & Polymer Chemistry: Potential monomer or cross-linking agent for creating advanced polymeric materials with specific electronic or optical properties.

Basic Information

Product Name	2-Amino-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1384855-33-7
Molecular Formula	C13H17BN2O2
Molecular Weight	244.10 g/mol
Synonyms	4-Cyano-3-aminophenylboronic acid pinacol ester; 2-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-aminobenzonitrile; 2-Amino-4-Bpin-benzonitrile; 2-Amino-4-(pinacolatoboron)benzonitrile; Boronic acid, B-[2-amino-4-cyanophenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.