Description

Methyl (3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate. Its primary value lies in enabling efficient, palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern organic synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing novel active ingredients, as well as for advanced material scientists working on functional polymers and organic electronics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in constructing biaryl and heterobiaryl scaffolds common in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic coupling steps.
• Material Science Research: Serves as a monomer or precursor for creating conjugated polymers and organic semiconductors used in OLEDs, OFETs, and sensors.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes (ABPs) and other tools for studying enzyme function and protein labeling.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing novel bidentate or tridentate ligands used in asymmetric catalysis.
• Academic & Contract Research: A versatile reagent for methodology development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Item	Details
Product Name	Methyl (3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate
CAS No.	1384313-38-5
Molecular Formula	C14H20BNO4
Molecular Weight	277.12 g/mol
Synonyms	3-((Methoxycarbonyl)amino)phenylboronic acid pinacol ester; Methyl N-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate; 3-Carbamoyloxyphenylboronic acid pinacol ester; (3-((Methoxycarbonyl)amino)phenyl)boronic acid pinacol ester; B-[3-[(Methoxycarbonyl)amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate
EINECS	Contact for details

Quality Control

Our Methyl (3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with full analytical data are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture will compromise purity and reactivity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.