Description

2-Bromo-1,4-Difluoro-5-(Methylthio)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of bromine, fluorine, and a methylthio group on the benzene ring, enabling precise molecular modifications and the introduction of key functionalities. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and substituents.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry Building Block: The difluoro motif is valuable for introducing fluorine atoms into target molecules to modulate their metabolic stability, lipophilicity, and binding affinity.
• Sulfur Chemistry Exploration: The methylthio group can be further functionalized or oxidized, providing a handle for creating sulfoxides, sulfones, or other sulfur-containing moieties.

Basic Information

Product Name	2-Bromo-1,4-Difluoro-5-(Methylthio)Benzene
CAS No.	1383968-48-6
Molecular Formula	C7H5BrF2S
Molecular Weight	239.08 g/mol
Synonyms	1-Bromo-2,5-difluoro-4-(methylthio)benzene; 5-Bromo-2,5-difluoro-4-(methylthio)benzene; 2-Bromo-1,4-difluoro-5-methylthiobenzene; Benzene, 2-bromo-1,4-difluoro-5-(methylthio)-; 1,4-Difluoro-2-bromo-5-(methylthio)benzene; 4-(Methylthio)-2,5-difluorobromobenzene; 1383968-48-6
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1,4-Difluoro-5-(Methylthio)Benzene is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and protect from prolonged exposure to light due to its light-sensitive nature.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.