Description

6,7-Dihydro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5H-Pyrazolo[5,1-B][1,3]Oxazine is a high-value, advanced pharmaceutical intermediate belonging to the class of heterocyclic boronic acid esters. This compound is critical for enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester reagent for forming carbon-carbon bonds under mild conditions, essential for constructing complex biaryl structures.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for API manufacturing under GMP conditions.
• Agrochemical Synthesis: Potential intermediate for creating novel herbicides or fungicides with specific activity profiles.
• Material Science Research: Exploration into organic electronic materials, such as OLEDs or organic semiconductors, where its fused heterocyclic structure may be beneficial.

Basic Information

Product Name	6,7-Dihydro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5H-Pyrazolo[5,1-B][1,3]Oxazine
CAS No.	1383675-83-9
Molecular Formula	C15H23BN2O3
Molecular Weight	290.17 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine; 6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-boronic acid pinacol ester; 1383675-83-9; Pyrazolo[5,1-b][1,3]oxazine-3-boronic acid, 6,7-dihydro-, pinacol ester; 3-(Pinacolatoboryl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine
EINECS	Contact for details

Quality Control

Our 6,7-Dihydro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5H-Pyrazolo[5,1-B][1,3]Oxazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area Percent)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.