Description

Ethyl 1-(((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Methyl)Cyclobutanecarboxylate is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds between the pyridine-boronate moiety and various aryl/heteroaryl halides.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with complex molecular architectures.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology: Employed in the synthesis of probes and tool compounds for target identification and validation.
• Process Chemistry: Utilized in route scouting and scale-up for the efficient production of target molecules.

Basic Information

Product Name	Ethyl 1-(((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Methyl)Cyclobutanecarboxylate
CAS No.	1383001-20-4
Molecular Formula	C21H32BNO5
Molecular Weight	389.30 g/mol
Synonyms	Ethyl 1-(((4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy)methyl)cyclobutanecarboxylate; 2-Pyridineboronic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[[(1-ethoxycarbonylcyclobutyl)methoxy]methyl]-4-methyl-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[[(1-ethoxycarbonylcyclobutyl)methoxy]methyl]-4-methylpyridine; Cyclobutanecarboxylic acid, 1-[[[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-pyridinyl]oxy]methyl]-, ethyl ester; CAS 1383001-20-4
EINECS	Contact for details

Quality Control

Our Ethyl 1-(((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Methyl)Cyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.