Description

Methyl 2,2-Dimethyl-3-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propanoate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl scaffolds. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS disorders, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing coupling partner for constructing carbon-carbon bonds between aromatic rings.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with complex molecular architectures.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a building block for linker molecules in the development of targeted protein degraders.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	Methyl 2,2-Dimethyl-3-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propanoate
CAS No.	1383000-29-0
Molecular Formula	C19H30BNO5
Molecular Weight	363.26 g/mol
Synonyms	2,2-Dimethyl-3-((4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy)propanoic acid methyl ester; Methyl 3-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-yl)oxy)-2,2-dimethylpropanoate; 2-Pyridinepropanoic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-, methyl ester, β,β-dimethyl-; Boronic acid, B-[2-[(2-methoxy-1,1-dimethyl-2-oxoethoxy)methyl]-4-methyl-5-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 1383000-29-0; Methyl 2,2-dimethyl-3-{[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}propanoate
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Dimethyl-3-((4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Oxy)Propanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.