Description

[(3R)-3-(Hydroxymethyl)-1-Piperidinyl][4-[2-(4-Methoxyphenyl)Ethynyl]Phenyl]-Methanone is a high-purity, non-racemic chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel, biologically active molecules, particularly within pharmaceutical research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate a specific, complex piperidine-based scaffold into their target structures.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) targets, kinase inhibitors, or other receptor modulators.
• Agrochemical Research: Used in the discovery and development of new active ingredients with specific stereochemical requirements for enhanced efficacy and selectivity.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular tools to study biological pathways and protein function.
• Asymmetric Catalysis Ligand Synthesis: A potential starting material for the preparation of novel chiral ligands or organocatalysts.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the exploration of new chemical space in medicinal chemistry.

Basic Information

Product Name	[(3R)-3-(Hydroxymethyl)-1-Piperidinyl][4-[2-(4-Methoxyphenyl)Ethynyl]Phenyl]-Methanone
CAS No.	1382481-79-9
Molecular Formula	C22H23NO3
Molecular Weight	349.43 g/mol
Synonyms	(R)-3-(Hydroxymethyl)-1-(4-((4-methoxyphenyl)ethynyl)benzoyl)piperidine; (3R)-3-(Hydroxymethyl)-1-[4-[2-(4-methoxyphenyl)ethynyl]benzoyl]piperidine; 1-[4-[(4-Methoxyphenyl)ethynyl]benzoyl]-3-piperidinemethanol, (3R)-; 1382481-79-9; (R)-1-(4-((4-Methoxyphenyl)ethynyl)benzoyl)piperidine-3-carbinol; Chiral Piperidine Alkyne Ketone Intermediate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of [(3R)-3-(Hydroxymethyl)-1-Piperidinyl][4-[2-(4-Methoxyphenyl)Ethynyl]Phenyl]-Methanone is characterized and tested for identity, purity, and chiral integrity using advanced analytical techniques. Certificates of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (HPLC), and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.