Description

1,3,2-Dioxaborolane, 2-[2-Fluoro-4-[(Methylsulfonyl)Methyl]Phenyl]-4,4,5,5-Tetramethyl- is a high-purity, organoboron building block featuring a pinacol boronate ester group and a functionalized aromatic ring. This compound is a critical intermediate in modern synthetic chemistry, enabling precise carbon-carbon and carbon-heteroatom bond formation. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heteroaryl structures in pharmaceutical intermediates.
• API (Active Pharmaceutical Ingredient) Synthesis: Used in the research and development of novel drug candidates, particularly those targeting CNS and oncology.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and functional polymers.
• Medicinal Chemistry & Lead Optimization: Facilitates the rapid exploration of structure-activity relationships (SAR) due to its versatile reactivity.
• Process Chemistry & Scale-up: Suitable for transitioning from laboratory-scale discovery to pilot and commercial manufacturing.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[2-Fluoro-4-[(Methylsulfonyl)Methyl]Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	1382136-98-2
Molecular Formula	C14H20BFO4S
Molecular Weight	314.18 g/mol
Synonyms	2-(2-Fluoro-4-((methylsulfonyl)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Fluoro-4-((methylsulfonyl)methyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-fluoro-4-(methylsulfonylmethyl)phenyl]-1,3,2-dioxaborolane; 2-Fluoro-4-((methylsulfonyl)methyl)benzeneboronic acid pinacol ester; Pinacol [2-fluoro-4-(methylsulfonylmethyl)phenyl]boronate; Boronic acid, B-[2-fluoro-4-[(methylsulfonyl)methyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-[2-Fluoro-4-[(Methylsulfonyl)Methyl]Phenyl]-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.