Description

(3E)-4-[2-Bromo-6-(Trifluoromethoxy)Phenyl]But-3-En-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its bromo- and trifluoromethoxy-substituted aromatic structure. This compound matters for its critical role as a sophisticated building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique halogenated and fluorinated motifs, which can enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and pesticides, where the trifluoromethoxy group is a valuable moiety for bioactivity.
• Material Science Precursor: Potential use in the synthesis of specialized organic electronic materials or liquid crystals, leveraging its conjugated system and halogen atoms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	(3E)-4-[2-Bromo-6-(Trifluoromethoxy)Phenyl]But-3-En-2-One
CAS No.	1381952-86-8
Molecular Formula	C11H8BrF3O2
Molecular Weight	309.08 g/mol
Synonyms	(E)-4-(2-Bromo-6-(trifluoromethoxy)phenyl)but-3-en-2-one; 4-(2-Bromo-6-(trifluoromethoxy)phenyl)-3-buten-2-one; 2-Bromo-6-(trifluoromethoxy)benzalacetone; 1-(2-Bromo-6-(trifluoromethoxy)phenyl)-3-buten-2-one; (3E)-4-[2-Bromo-6-(trifluoromethoxy)phenyl]-3-buten-2-one; 1381952-86-8; But-3-en-2-one, 4-[2-bromo-6-(trifluoromethoxy)phenyl]-, (3E)-
EINECS	Contact for details

Quality Control

Our (3E)-4-[2-Bromo-6-(Trifluoromethoxy)Phenyl]But-3-En-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, identity confirmation (IR, NMR), and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.