Description

Bromo-Peg2-T-Butyl Ester is a high-purity bifunctional PEG derivative featuring a reactive bromo group and a protected carboxylic acid. This compound is a crucial building block for the synthesis of functionalized linkers, spacers, and conjugates in advanced chemical and biological research. It is primarily utilized by researchers and process developers in the pharmaceutical, biotech, and advanced materials sectors for creating tailored molecular architectures.

Application

• Pharmaceutical Linker Synthesis: Serves as a key intermediate for constructing antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted therapeutic agents.
• Polymer Functionalization: Used to introduce reactive bromo handles or protected carboxyl groups into polymer backbones for further modification and cross-linking.
• Bioconjugation Chemistry: Acts as a heterobifunctional crosslinker for attaching drugs, dyes, or other payloads to proteins, peptides, or nanoparticles.
• Proteolysis-Targeting Chimera (PROTAC) Development: Employed as a flexible linker component to connect E3 ligase ligands to target protein ligands.
• Surface Modification: Facilitates the functionalization of surfaces, such as glass, gold, or magnetic beads, for biosensor and diagnostic assay development.
• Material Science Research: Enables the creation of novel hydrogels, smart materials, and functional coatings with specific chemical handles.

Basic Information

Product Name	Bromo-Peg2-T-Butyl Ester
CAS No.	1381861-91-1
Molecular Formula	C13H25BrO5
Molecular Weight	341.24 g/mol
Synonyms	2-[2-(2-Bromoethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-bromoethoxy)ethoxy]acetate; Bromo-PEG2-t-butyl ester; Bromo-dPEG®2-t-butyl ester; 1-Bromo-2-[2-(tert-butoxy)-2-oxoethoxy]ethoxyethane; Bromo-PEG2-acid t-butyl ester; t-Butyl bromo-PEG2-acetate
EINECS	Contact for details

Quality Control

Our Bromo-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.