Description

Methyl 3-Bromo-4-Fluoro-2-Methylbenzoate is a high-purity, multi-functional aromatic ester building block critical for advanced organic synthesis. Its value lies in the strategic positioning of halogen substituents (bromo and fluoro) and the methyl ester group, which enable precise molecular modifications and scaffold diversification. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex heterocycles and fine-tuning the physicochemical properties of lead compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring halogenated benzoate motifs.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille), nucleophilic aromatic substitution, and ester hydrolysis/transformation to access a wide array of derivatives.
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Methyl 3-Bromo-4-Fluoro-2-Methylbenzoate
CAS No.	1380305-66-7
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	3-Bromo-4-fluoro-2-methylbenzoic acid methyl ester; Methyl 3-bromo-4-fluoro-o-toluate; Benzoic acid, 3-bromo-4-fluoro-2-methyl-, methyl ester; 2-Methyl-3-bromo-4-fluorobenzoic acid methyl ester; 3-Bromo-4-fluoro-2-methyl methylbenzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Bromo-4-Fluoro-2-Methylbenzoate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications including identity confirmation, assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment, and our quality management system supports compliance with cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.