Description

1H-Pyrazole, 1-[(4-Fluorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, featuring a protected boronic acid group and a fluorinated aromatic system, enabling precise cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients. CAS No. 1379615-58-3.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex drug candidates, particularly in kinase inhibitor and CNS-active molecule development.
• Agrochemical Synthesis: Used to construct fluorinated heterocyclic scaffolds found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes (ABPs) and molecular tags for studying enzyme function and protein interactions.
• Library Synthesis for Drug Discovery: A versatile building block for creating diverse compound libraries via high-throughput parallel synthesis.
• Ligand Synthesis for Catalysis: Used to prepare specialized pyrazole-based ligands for transition metal catalysts.

Basic Information

Item	Details
Product Name	1H-Pyrazole, 1-[(4-Fluorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1379615-58-3
Molecular Formula	C16H22BFN2O2
Molecular Weight	304.17 g/mol
Synonyms	1-[(4-Fluorobenzyl)]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(4-Fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-fluorobenzyl)-1H-pyrazole; 1-(4-Fluorobenzyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-[(4-fluorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1379615-58-3; 1-(4-Fluorobenzyl)-4-(pinacolboryl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole, 1-[(4-Fluorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation, as boronic esters can be sensitive to hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.