Description

3-(Bromomethyl)-5-Fluorobenzaldehyde is a versatile and high-purity fluorinated aromatic building block. This compound is critical for the synthesis of complex molecules, offering a reactive bromomethyl handle and an aldehyde functional group for diverse chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that require fluorinated aromatic cores.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel fluorinated polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-(Bromomethyl)-5-Fluorobenzaldehyde
CAS No.	1379358-86-7
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	5-Fluoro-3-(bromomethyl)benzaldehyde; 3-Bromomethyl-5-fluorobenzaldehyde; (3-Bromomethyl-5-fluorophenyl)methanal; 5-Fluoro-3-bromomethylbenzaldehyde; Benzaldehyde, 3-(bromomethyl)-5-fluoro-; 1379358-86-7; 3-Bromomethyl-5-fluorobenzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 3-(Bromomethyl)-5-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.