Description

Methyl 6-Chloro-2-Fluoro-3-Methoxybenzoate is a high-purity fluorinated benzoate ester, serving as a critical advanced pharmaceutical intermediate (API intermediate) and versatile building block in organic synthesis. Its value lies in its precise molecular architecture, which enables the efficient construction of complex molecules for life sciences research and development. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the chloro-fluoro-methoxy substitution pattern.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique electronic or optical properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and functional group transformations to create complex molecular libraries for drug discovery.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	Methyl 6-Chloro-2-Fluoro-3-Methoxybenzoate
CAS No.	1379296-92-0
Molecular Formula	C9H8ClFO3
Molecular Weight	218.61 g/mol
Synonyms	Methyl 6-chloro-2-fluoro-3-methoxybenzoate; 6-Chloro-2-fluoro-3-methoxybenzoic acid methyl ester; 2-Fluoro-6-chloro-3-methoxybenzoic acid methyl ester; Benzoic acid, 6-chloro-2-fluoro-3-methoxy-, methyl ester; Methyl 2-fluoro-6-chloro-3-methoxybenzoate; CAS 1379296-92-0
EINECS	Contact for details

Quality Control

Our Methyl 6-Chloro-2-Fluoro-3-Methoxybenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.