Description

4-Bromo-3-(Trifluoromethoxy)Benzyl Bromide is a versatile and highly functionalized benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of both bromine and trifluoromethoxy substituents, which are essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used to create novel herbicides and fungicides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in cross-coupling catalysis and material science.
• Liquid Crystal and OLED Material Research: The benzyl core and halogenated motifs are valuable for constructing aromatic units in electronic and display materials.
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for producing bespoke compounds for client-specific projects.
• Fluorine Chemistry Studies: An important substrate for investigating the influence of the -OCF3 group on reaction pathways and molecular properties.

Basic Information

Product Name	4-Bromo-3-(Trifluoromethoxy)Benzyl Bromide
CAS No.	1378869-35-2
Molecular Formula	C8H5Br2F3O
Molecular Weight	333.93 g/mol
Synonyms	1-(Bromomethyl)-4-bromo-3-(trifluoromethoxy)benzene; α,4-Dibromo-α-(trifluoromethoxy)toluene; (4-Bromo-3-(trifluoromethoxy)phenyl)methyl bromide; 4-Bromo-3-(trifluoromethoxy)benzyl bromide; Benzene, 1-(bromomethyl)-4-bromo-3-(trifluoromethoxy)-; 3-Trifluoromethoxy-4-bromobenzyl bromide
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.