Description

2-[2-(3,4-Difluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a vinylboronic ester, designed for advanced cross-coupling reactions. Its core value lies in enabling the precise and efficient synthesis of complex fluorinated organic molecules, which are critical in modern pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and functional organic electronic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing difluorophenyl motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the introduction of specific fluorinated aromatic systems is required for enhanced activity.
• Material Science Research: Serves as a monomer or building block for creating fluorinated polymers, liquid crystals, and organic light-emitting diodes (OLEDs) with tailored electronic properties.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Process Chemistry: Utilized in scale-up and optimization of manufacturing routes for fluorinated fine chemicals under GMP-like conditions.

Basic Information

Item	Details
Product Name	2-[2-(3,4-Difluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1377151-58-0
Molecular Formula	C14H17BF2O2
Molecular Weight	266.10 g/mol
Synonyms	1,3,2-Dioxaborolane, 2-[2-(3,4-difluorophenyl)ethenyl]-4,4,5,5-tetramethyl-; (2-(3,4-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,4-Difluorostyrylboronic Acid Pinacol Ester; 2-(3,4-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[2-(3,4-difluorophenyl)vinyl]-1,3,2-dioxaborolane; (E)-2-(3,4-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Vinylboronic Acid Pinacol Ester, 3,4-Difluoro-
EINECS	Contact for details

Quality Control

Every batch of our 2-[2-(3,4-Difluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is produced and tested under stringent quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling chemistry. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.