Description

6-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling the Suzuki-Miyaura cross-coupling reaction, a powerful method for forming carbon-carbon bonds with high efficiency and functional group tolerance. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require precise, scalable synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the pyridine-amine-boronate structure introduces specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands for transition metal catalysis, enhancing reaction selectivity and yield.
• Chemical Biology Probes: Utilized to create labeled compounds or molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	6-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
CAS No.	1375708-04-5
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	2-Amino-6-methoxy-3-pyridineboronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methoxypyridin-2-amine; 6-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine; 6-Methoxy-5-(pinacolatoboryl)pyridin-2-amine; 2-Pyridinamine, 6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 6-Amino-2-methoxypyridine-3-boronate
EINECS	Contact for details

Quality Control

Our 6-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H and 13C), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for optimal shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.