Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazoline is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This advanced intermediate is essential for researchers and manufacturers in pharmaceutical development and agrochemical synthesis who require reliable, high-quality reagents for creating novel quinazoline-based compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting oncology, CNS disorders, and inflammatory diseases.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with quinazoline cores.
• Material Science: Used in the creation of organic electronic materials, such as OLED emitters and charge-transport layers.
• Chemical Biology & Probe Development: Enables the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Academic & Contract Research: A versatile reagent for methodology development and library synthesis in academic and CRO laboratories.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale production of target molecules.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazoline
CAS No.	1375301-92-0
Molecular Formula	C₁₅H₁₉BN₂O₂
Molecular Weight	270.14 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; Quinazoline-6-boronic acid pinacol ester; 6-(Pinacolboranyl)quinazoline; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-quinazoline; 6-Quinazolineboronic acid pinacol ester; 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; 1375301-92-0; BRN 15358812
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and prolong shelf-life. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.