Description

7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazoline is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of quinazoline-based drug candidates, including potential kinase inhibitors for oncology and other therapeutic areas.
• Agrochemical Synthesis: Used in research and development of new herbicides, fungicides, and insecticides that incorporate the quinazoline scaffold.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Academic & Industrial R&D: A versatile reagent for methodological development in cross-coupling chemistry and the construction of heterocyclic libraries.
• Scale-up Process Chemistry: Supplied for process optimization and pilot-scale synthesis of target molecules in commercial development pipelines.

Basic Information

Product Name	7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazoline
CAS No.	1375108-46-5
Molecular Formula	C₁₅H₁₉BN₂O₂
Molecular Weight	270.14 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; Quinazoline-7-boronic acid pinacol ester; 7-(Pinacolboryl)quinazoline; 7-Quinazolineboronic acid pinacol ester; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; 7-Boronoquinazoline pinacol ester; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolanyl)quinazoline
EINECS	Contact for details

Quality Control

Our 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Quinazoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting our commitment to reliable supply for research and commercial scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.