Description

2-(Benzyloxy)-1-Fluoro-4-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a benzyloxy ether, a fluorine atom, and a trifluoromethoxy group, which imparts desirable properties like enhanced lipophilicity and metabolic stability to target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in medicinal chemistry, particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Serves as a critical building block in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve bioactivity and environmental profile.
• Material Science Precursor: Used in the synthesis of specialty monomers and polymers, such as polyaryl ethers, which can exhibit high thermal stability and specific optical properties.
• Liquid Crystal & OLED Materials: Acts as a fluorinated core unit in the design of advanced electronic display materials, contributing to improved charge transport and emission characteristics.
• Chemical Biology Probes: Employed in the creation of fluorinated probes and tags for studying biological processes and protein interactions via techniques like 19F NMR spectroscopy.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	2-(Benzyloxy)-1-Fluoro-4-(Trifluoromethoxy)Benzene
CAS No.	1375069-09-2
Molecular Formula	C14H10F4O2
Molecular Weight	286.22 g/mol
Synonyms	1-Fluoro-2-(benzyloxy)-4-(trifluoromethoxy)benzene; 2-Benzyloxy-1-fluoro-4-trifluoromethoxybenzene; 1-Fluoro-4-(trifluoromethoxy)-2-(phenylmethoxy)benzene; Benzene, 2-(benzyloxy)-1-fluoro-4-(trifluoromethoxy)-; 2-(Benzyloxy)-1-fluoro-4-(trifluoromethoxy)benzene; 1375069-09-2
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-1-Fluoro-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support development from research to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.