Description

1-Boc-3-Fluoroazetidine-3-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine scaffold with both a fluoro substituent and a protected aldehyde functionality. This compound is critical for medicinal chemists seeking to introduce conformational constraint and modulate the physicochemical properties of drug candidates. It is primarily utilized in the research and development of novel therapeutics, including kinase inhibitors and other small molecule drugs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the fluorinated azetidine moiety on potency, selectivity, and metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its reactive aldehyde group, which can be further functionalized.
• Chemical Biology Probes: Employed in the creation of tool compounds for investigating biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of novel, high-performance crop protection agents.

Basic Information

Product Name	1-Boc-3-Fluoroazetidine-3-Carbaldehyde
CAS No.	1374658-52-2
Molecular Formula	C9H14FNO3
Molecular Weight	203.21 g/mol
Synonyms	tert-Butyl 3-fluoro-3-formylazetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-fluoroazetidine-3-carboxaldehyde; 3-Fluoro-3-formylazetidine-1-carboxylic acid tert-butyl ester; 3-Fluoro-1-Boc-azetidine-3-carbaldehyde; 1-Boc-3-fluoro-3-carbaldehyde azetidine; 3-Fluoroazetidine-3-carbaldehyde-1-Boc; Boc-3-fluoro-azetidine-3-carboxaldehyde; 3-Fluoro-3-(1-Boc-azetidin-3-yl)carbaldehyde
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Fluoroazetidine-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.