Description

3-(Boc-Amino)-3-Fluoroazetidine is a high-purity, fluorinated azetidine derivative protected with a tert-butoxycarbonyl (Boc) group. This compound serves as a critical, advanced pharmaceutical intermediate, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for research and development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce fluorine and the constrained azetidine ring system into novel molecules.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation platforms.
• Covalent Inhibitor Synthesis: The fluorinated azetidine scaffold can be leveraged in the design of covalent inhibitors for specific enzyme targets.
• Peptidomimetics: Incorporated into peptide analogs to improve pharmacological properties such as membrane permeability and resistance to enzymatic degradation.
• Agrochemical Research: Potential intermediate in the development of new fluorinated agrochemicals with improved efficacy.

Basic Information

Product Name	3-(Boc-Amino)-3-Fluoroazetidine
CAS No.	1374657-58-5
Molecular Formula	C8H15FN2O2
Molecular Weight	190.22 g/mol
Synonyms	3-Fluoro-3-[(tert-butoxycarbonyl)amino]azetidine; tert-Butyl (3-fluoroazetidin-3-yl)carbamate; 3-[(tert-Butoxycarbonyl)amino]-3-fluoroazetidine; 3-Fluoro-3-[(Boc)amino]azetidine; 3-(Boc-amino)-3-fluoroazetidine; Boc-3-amino-3-fluoroazetidine; (3-Fluoroazetidin-3-yl)carbamic acid tert-butyl ester; 1,1-Dimethylethyl N-(3-fluoro-3-azetidinyl)carbamate
EINECS	Contact for details

Quality Control

Our 3-(Boc-Amino)-3-Fluoroazetidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports your R&D and cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.