Description

2-(3,3-Difluorocyclobutyl)Acetaldehyde is a high-value fluorinated building block and aldehyde intermediate. This compound matters for its unique cyclobutyl scaffold and difluoro substitution, which are critical for modulating the physicochemical properties of target molecules in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the difluorocyclobutyl group can enhance bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials that require fluorinated components for specific thermal or chemical resistance properties.
• Organic Synthesis Reagent: Employed in various organic transformations, including reductive amination, Grignard reactions, and as a precursor for heterocycle formation.
• Ligand and Catalyst Development: Useful in the design and synthesis of novel chiral ligands or organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on understanding the effects of gem-difluoro groups on cyclobutane ring systems.

Basic Information

Product Name	2-(3,3-Difluorocyclobutyl)Acetaldehyde
CAS No.	1374657-08-5
Molecular Formula	C6H8F2O
Molecular Weight	134.12 g/mol
Synonyms	3,3-Difluorocyclobutanecarbaldehyde; 3,3-Difluorocyclobutanecarboxaldehyde; 2-(3,3-Difluorocyclobutyl)Ethanal; 3,3-Difluorocyclobutylacetaldehyde; (3,3-Difluorocyclobutyl)Acetaldehyde; 1374657-08-5; 2-(3,3-Difluorocyclobutyl)Acetaldehyde
EINECS	Contact for details

Quality Control

Our 2-(3,3-Difluorocyclobutyl)Acetaldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.