Description

1-(2-(Trimethylsilyl)Ethylsulfonyl)-1H-Indol-7-Amine is a specialized organosilicon-sulfonyl indole derivative, a high-value building block in advanced organic synthesis. Its unique molecular architecture, featuring both a silyl-protected sulfonyl group and a reactive amine on the indole core, makes it a critical intermediate for constructing complex pharmacophores. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its unique indole-sulfonyl scaffold.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced materials.
• Chemical Biology Probe Development: Utilized to create labeled compounds or activity-based probes for studying biological pathways.
• Organic Synthesis Reagent: Acts as a versatile intermediate in multi-step synthetic routes for complex heterocyclic compounds.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	1-(2-(Trimethylsilyl)Ethylsulfonyl)-1H-Indol-7-Amine
CAS No.	1374652-49-9
Molecular Formula	C13H20N2O2SSi
Molecular Weight	296.47 g/mol
Synonyms	7-Amino-1-[(2-trimethylsilyl)ethylsulfonyl]-1H-indole; 1H-Indol-7-amine, 1-[(2-(trimethylsilyl)ethyl)sulfonyl]-; 1-(2-Trimethylsilylethanesulfonyl)-1H-indol-7-amine; 1-(2-TMS-ethylsulfonyl)-1H-indol-7-amine; 7-Amino-1-(2-trimethylsilylethylsulfonyl)indole; TES-Indol-7-amine; 1-(2-(Trimethylsilyl)ethanesulfonyl)-1H-indol-7-amine
EINECS	Contact for details

Quality Control

Our production of 1-(2-(Trimethylsilyl)Ethylsulfonyl)-1H-Indol-7-Amine adheres to stringent quality management protocols. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting purity, assay, and impurity profiles. Our quality system is designed to support cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.