Description

2-Bromo-1-(4-(Trifluoromethyl)Phenyl)Ethanone Hydrochloride is a high-purity, halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a reactive α-bromo ketone moiety and a stable trifluoromethylphenyl group, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Used in the synthesis of advanced organic materials, including liquid crystals, organic semiconductors, and polymers with specific optical or electronic properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) agents due to its electrophilic warhead.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce complex aromatic systems.
• Heterocyclic Compound Synthesis: A valuable starting material for the construction of various nitrogen- and oxygen-containing heterocycles, which are core structures in many bioactive molecules.

Basic Information

Product Name	2-Bromo-1-(4-(Trifluoromethyl)Phenyl)Ethanone Hydrochloride
CAS No.	1374652-45-5
Molecular Formula	C9H7BrClF3O
Molecular Weight	303.50 g/mol
Synonyms	2-Bromo-1-[4-(trifluoromethyl)phenyl]ethan-1-one hydrochloride; 2-Bromo-4'-trifluoromethylacetophenone hydrochloride; α-Bromo-4'-(trifluoromethyl)acetophenone hydrochloride; 4'-Trifluoromethylphenacyl bromide hydrochloride; 1-(4-Trifluoromethylphenyl)-2-bromoethanone hydrochloride; TFMPAB hydrochloride; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(4-(Trifluoromethyl)Phenyl)Ethanone Hydrochloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.