Description

2-(4-Chloro-2,6-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1374578-82-1 is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and agrochemical development. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific chlorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to introduce the 4-chloro-2,6-dimethylphenyl moiety into target molecules.
• Ligand and Catalyst Development: Utilized in the synthesis of specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the creation of molecular probes for biological studies.

Basic Information

Product Name	2-(4-Chloro-2,6-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1374578-82-1
Molecular Formula	C14H20BClO2
Molecular Weight	266.57 g/mol
Synonyms	4-Chloro-2,6-dimethylbenzeneboronic acid pinacol ester; (4-Chloro-2,6-dimethylphenyl)boronic acid pinacol ester; 2-(4-Chloro-2,6-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-2,6-dimethylphenylboronic acid pinacol ester; Pinacol (4-chloro-2,6-dimethylphenyl)boronate; 1374578-82-1; 4-Chloro-2,6-dimethylbenzeneboronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chloro-2,6-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemicals and advanced intermediates. Comprehensive analytical testing, including HPLC, NMR, and GC, is performed to guarantee identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.