Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenemethanol is a valuable boronic ester derivative, serving as a key protected boronic acid building block for advanced organic synthesis. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing biaryl and heterobiaryl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific boronic acid coupling steps.
• Material Science Research: Employed in the creation of organic electronic materials, polymers, and liquid crystals where precise molecular assembly is required.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a stable, air-handleable alternative to sensitive boronic acids for palladium-catalyzed carbon-carbon bond formation.
• Chemical Biology & Proteomics: Utilized as a synthetic handle for bioconjugation and the development of molecular probes and sensors.
• Academic & Industrial R&D: Serves as a versatile reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Item	Details
Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenemethanol
CAS No.	1374294-47-9
Molecular Formula	C13H19BO3
Molecular Weight	234.10 g/mol
Synonyms	(2-(Hydroxymethyl)phenyl)boronic acid pinacol ester; 2-(Hydroxymethyl)benzeneboronic acid pinacol ester; Benzenemethanol, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-(Pinacolatoboryl)benzyl alcohol; 2-(Benzyl alcohol)pinacol boronate; 2-(Hydroxymethyl)phenylboronic acid pinacol ester; 2-(Pinacolboron)benzyl alcohol
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzenemethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and compliance with customer requirements for research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.