Description

(R)-3-(tert-Butyldimethylsilyloxy) Piperidine is a high-value, chiral piperidine derivative protected with a tert-butyldimethylsilyl (TBDMS) group. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) therapeutics and other specialized medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective chemical reactions to introduce the (R)-configured piperidine moiety.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for drug discovery projects.
• CNS Drug Development: A valuable scaffold for synthesizing potential therapeutics targeting neurological and psychiatric disorders.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and route development for GMP manufacturing.
• Academic Research: Used in synthetic organic chemistry studies focusing on heterocycle and natural product synthesis.

Basic Information

Product Name	(R)-3-(tert-Butyldimethylsilyloxy) Piperidine
CAS No.	1374144-82-7
Molecular Formula	C11H25NOSi
Molecular Weight	215.41 g/mol
Synonyms	(R)-3-[(tert-Butyldimethylsilyl)oxy]piperidine; (R)-3-(TBDMSO)piperidine; (3R)-3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]piperidine; Piperidine, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R)-; (R)-N-Boc-3-(tert-butyldimethylsilyloxy)piperidine (related protected form); (R)-3-Hydroxypiperidine TBDMS ether; (R)-3-OTBDMS-piperidine
EINECS	Contact for details

Quality Control

Our (R)-3-(tert-Butyldimethylsilyloxy) Piperidine is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.