Description

6-Chloro-2,3-Difluoroacetophenone, 97% is a high-purity fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target structures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially those containing difluoromethyl or trifluoromethyl groups.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the chloro-difluoroacetophenone scaffold provides desirable biological activity.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials requiring halogenated aromatic components.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for creating complex biaryl systems.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	6-Chloro-2,3-Difluoroacetophenone, 97%
CAS No.	1373920-86-5
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(6-Chloro-2,3-difluorophenyl)ethan-1-one; 2',3'-Difluoro-6'-chloroacetophenone; 6-Chloro-2,3-difluoroacetophenone; 2,3-Difluoro-6-chloroacetophenone; 1-(6-Chloro-2,3-difluorophenyl)ethanone; Acetophenone, 6-chloro-2,3-difluoro-; Ethanone, 1-(6-chloro-2,3-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,3-Difluoroacetophenone, 97% undergoes rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed using advanced techniques like HPLC, GC, and NMR to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, providing full transparency and traceability for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.