Description

4-Cyano-1H-Indole-2-Boronic Acid is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a boronic acid functional group and a cyano-substituted indole scaffold, enabling precise carbon-carbon bond formation via cross-coupling reactions. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics targeting oncology and CNS disorders.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl systems under palladium catalysis.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the indole core's bioactivity.
• Material Science: Employed in the creation of organic electronic materials, such as OLED emitters and charge-transport molecules, where the indole unit provides desirable photophysical properties.
• Chemical Biology & Probe Development: Utilized as a scaffold for creating fluorescent probes or activity-based protein profiling (ABPP) reagents.
• Library Synthesis for High-Throughput Screening: A valuable building block for generating diverse compound libraries in medicinal chemistry campaigns.

Basic Information

Product Name	4-Cyano-1H-Indole-2-Boronic Acid
CAS No.	1373834-76-4
Molecular Formula	C9H7BN2O2
Molecular Weight	186.98 g/mol
Synonyms	2-Borono-4-cyano-1H-indole; 4-Cyano-1H-indole-2-boronic acid; (4-Cyano-1H-indol-2-yl)boronic acid; 4-CN-1H-Indole-2-BA; 4-Cyanoindole-2-boronic acid; 1H-Indole-2-boronic acid, 4-cyano-; B-(4-Cyano-1H-indol-2-yl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Cyano-1H-Indole-2-Boronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling and medicinal chemistry applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.